Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy
Copyright policy )Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy
SignificanceThe etiology of heart disorders remains poorly understood. In this paper, we show for the first time to our knowledge, that protein palmitoylation plays a critical role in heart structure and function. We demonstrate that Aph2 (Ablphilin 2) is a palmitoyl transferase and identify phospholamban, a cardiomyopathy disease gene, as a substrate. Some of the heart defects of anAph2−/−mouse can be rescued by phospholamban ablation. In addition, the present study reveals critical roles for protein palmitoylation in embryonic/postnatal survival and eye development.
- Zhejiang Ocean University China (People's Republic of)
- Inserm France
- Shanghai Jiao Tong University China (People's Republic of)
- Département Sciences sociales, agriculture et alimentation, espace et environnement France
- Columbia University United States
572, [SDV]Life Sciences [q-bio], Lipoylation, Calcium-Binding Proteins, Eye, [SDV] Life Sciences [q-bio], Mice, Echocardiography, COS Cells, Chlorocebus aethiops, Animals, Phosphorylation, Cardiomyopathies, Carrier Proteins, Acyltransferases
572, [SDV]Life Sciences [q-bio], Lipoylation, Calcium-Binding Proteins, Eye, [SDV] Life Sciences [q-bio], Mice, Echocardiography, COS Cells, Chlorocebus aethiops, Animals, Phosphorylation, Cardiomyopathies, Carrier Proteins, Acyltransferases
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