AbstractSuberosis is one of the most common Hypersensitivity Pneumonitis (HP) in Portugal. Compared with Bird Fancier’s Disease (BFD), patients with Suberosis have predominately subacute and chronic presentations of HP. Although BAL CD8+ lymphocytes predominate in both diseases, CD4/CD8 ratio is significantly higher in BFD. Apart from these interstitial forms, in the initial descriptions of Suberosis asthma-like syndromes were also reported. We have recently described cases of Cork worker’s Occupational Asthma, associated with bronchoalveolar eosinophilic inflammation. While patients with HP had high IgG reactivity tomoulds and especially recognized Penicillium glabrum antigens of molecular weight of 12-13.5kDa and 33kDa, we could not find evidence of IgE sensitisation to these fungi in asthmatics.Cork worker’s Hypersensitivity Pneumonitis has a different clinical profile compared with Bird Fancier’s Disease, suggesting that different antigenic ex-posures may result in a different dynamic of the lung immune/inflammatory response. The identification of major antigens in cork worker’s HP (like those identified by immunoblotting in Penicillium glabrum) may be helpful to develop new diagnostic tests.