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Repurposing the HCV NS3–4A protease drug boceprevir as COVID-19 therapeutics

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2021 Netherlands, Germany English Publisher:Royal Society of Chemistry (RSC)Journal:RSC Medicinal Chemistry, volume 12, pages 370-379 (eissn: 2632-8682, Copyright policy )Funded by:NWO | Identification of pan-ant..., EC | PRONKJEWAIL, EC | DRIVE
Authors: Oerlemans, Rick; Ruiz-Moreno, Angel Jonathan; Cong, Yingying; Dinesh Kumar, Nilima; Velasco-Velazquez, Marco A; Neochoritis, Constantinos G; Smith, Jolanda; +3 Authors

doi: 10.1039/d0md00367k , 10.3204/pubdb-2023-00887

pmid: 34041486

pmc: PMC8130630

handle: 11370/bcf4c3b2-29dd-4d01-8a9c-b7c67645be6e

Repurposing the HCV NS3–4A protease drug boceprevir as COVID-19 therapeutics

Abstract

α-Ketoamide HCV protease inhibitors covalently bind to SARS-CoV-2 3CLpro. Boceprevir is a particular promising repurposed drug as it potently inhibits cellular viral proliferation.

Countries
Netherlands, Germany
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Keywords

Chemistry, info:eu-repo/classification/ddc/540, 540

  • BIP!
    Impact byBIP!
    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 61
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
61
Top 1%
Top 10%
Top 1%
Green
hybrid
Related to Research communities
Corona Virus Disease
Knowmad Institut
Netherlands Research Portal
UArctic