Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
Copyright policy )Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
(N Engl J Med. 2016;374:233–241) It is possible that peripartum cardiomyopathy is influenced by genetic factors, though this remains unclear. Similar to idiopathic dilated cardiomyopathy, this disease is associated with decreased systolic function, enlarged cardiac dimensions, and nonspecific histologic findings. These similarities are significant in that idiopathic dilated cardiomyopathy has been shown to be caused by a number of gene mutations. The authors of this study sequenced the DNA of 172 women suffering from peripartum cardiomyopathy to investigate whether there was a contribution from variants in the 43 genes known to be associated with dilated cardiomyopathy.
- National Institute for Health Research United Kingdom
- Hannover Medical School Germany
- Wake Forest Baptist Medical Center United States
- National University of Singapore Singapore
- Johns Hopkins Medicine United States
Adult, Cardiomyopathy, Dilated, Pregnancy Complications, Cardiovascular, 590, 610, Genetics and Genomics, Stroke Volume, Sequence Analysis, DNA, Pregnancy, Case-Control Studies, Mutation, Peripartum Period, Humans, Protein Isoforms, Connectin, Female, Genetic Predisposition to Disease, Cardiomyopathies
Adult, Cardiomyopathy, Dilated, Pregnancy Complications, Cardiovascular, 590, 610, Genetics and Genomics, Stroke Volume, Sequence Analysis, DNA, Pregnancy, Case-Control Studies, Mutation, Peripartum Period, Humans, Protein Isoforms, Connectin, Female, Genetic Predisposition to Disease, Cardiomyopathies
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