HLA-A, -B, -DR and -DQ allele and haplotype frequencies in the Moroccan population: a general population study
Copyright policy )HLA-A, -B, -DR and -DQ allele and haplotype frequencies in the Moroccan population: a general population study
The aim of this general population study is to extend our knowledge about the HLA-A, -B, -DR and -DQ genes distribution and their diversity among the Moroccan population.One hundred and ten unrelated healthy Moroccans from diverse regions of the country were included in the study. HLA typing was done either by serological (standard complement dependent microlymphocytotoxicity) and/or molecular (sequence-specific primer amplification) techniques.The most frequent alleles observed were: HLA-A2 (19.1%), -A1 (10%), -A3 (10%), -B44 (9.6%), -DR3 (17.1%), -DR4 (15.3%), -DQ2 (30.6%), -DQ6 (26.4%) and -DQ3 (25%). No predominant haplotype was observed for HLA A-B while high frequency was observed for some HLA DR-DQ associations (DR3-DQ2, DR15-DQ6, DR7-DQ2, DR4-DQ3, DR13-DQ6). Comparison with neighbouring populations, on the basis of alleles, haplotypes and genetic distances, showed that Moroccan population is close to the Algerians, the Tunisians, the Spaniards and the French. The haplotype frequencies revealed also relationships with Italians, Sardinians, Basques, Portuguese and Moroccan Jews populations.Our results confirm and extend the current knowledge about the Moroccan genetic pattern and reflect all the ethnic diversity of the country. This study will be helpful in the future for clinical analysis like transplantation and HLA-associated diseases in Moroccan population.
- Centre Hospitalier Ibn Sina Morocco
Adult, Male, HLA-A Antigens, Black People, Blood Donors, HLA-DR Antigens, Middle Aged, Tissue Donors, White People, Morocco, Genetics, Population, Gene Frequency, Haplotypes, HLA-B Antigens, HLA-DQ Antigens, Humans, Female
Adult, Male, HLA-A Antigens, Black People, Blood Donors, HLA-DR Antigens, Middle Aged, Tissue Donors, White People, Morocco, Genetics, Population, Gene Frequency, Haplotypes, HLA-B Antigens, HLA-DQ Antigens, Humans, Female
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).27 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!