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Cell
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Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2001Publisher:Elsevier BVJournal:Cell, volume 104, pages 875-889 (issn: 0092-8674, Copyright policy )
Authors: Jennifer S. Colvin; David M. Ornitz; Rebecca P. Green; Blanche Capel; Jennifer Schmahl;

doi: 10.1016/s0092-8674(01)00284-7

pmid: 11290325

Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

Abstract

Fgfs direct embryogenesis of several organs, including the lung, limb, and anterior pituitary. Here we report male-to-female sex reversal in mice lacking Fibroblast growth factor 9 (Fgf9), demonstrating a novel role for FGF signaling in testicular embryogenesis. Fgf9(-/-) mice also exhibit lung hypoplasia and die at birth. Reproductive system phenotypes range from testicular hypoplasia to complete sex reversal, with most Fgf9(-/-) XY reproductive systems appearing grossly female at birth. Fgf9 appears to act downstream of Sry to stimulate mesenchymal proliferation, mesonephric cell migration, and Sertoli cell differentiation in the embryonic testis. While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species.

Related Organizations
Keywords

Fibroblast Growth Factor 9, Male, Mice, Knockout, Sex Differentiation, Biochemistry, Genetics and Molecular Biology(all), Ovary, Restriction Mapping, Disorders of Sex Development, High Mobility Group Proteins, SOX9 Transcription Factor, Genitalia, Female, Genitalia, Male, Fibroblast Growth Factors, Embryonic and Fetal Development, Mice, Testis, Animals, Female, Transcription Factors

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 499
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
499
Top 1%
Top 1%
Top 1%
hybrid