Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis
Copyright policy )Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis
Abstract: In the current study, we investigated human leukocyte antigen (HLA) class II alleles in Caucasian women with primary biliary cirrhosis (PBC), a disease that preferentially affects women. Alleles of DRB1, DQA1, and DQB1 were determined by DNA‐based HLA typing for women with PBC (n = 72) and healthy women (n = 381). All study subjects were Caucasian. HLA DRB1*08 was significantly increased in women with PBC compared to healthy women. The increase was primarily due to the DRB1*0801 allele, also the most common DRB1*08 allele among controls. DQB1*04 and DQA1*0401 were significantly increased. DRB1*1501, DQA1*0102, and DQB1*0602 were associated with decreased risk. Analyses conducted comparing parous women with PBC to parous healthy women (n = 68 and n = 282, respectively) yielded similar significant results. Although the DRB1*08‐DQA1*0401‐DQB1*04 haplotype was significantly associated with PBC, consistent with other studies, this haplotype nevertheless represented only 19% (14/72) of all PBC patients and can account for only a minority of the risk of PBC.
- University of Washington United States
- Fred Hutchinson Cancer Research Center South Africa
- University of Mary United States
- Fred Hutchinson Cancer Research Center United States
Adult, Membrane Glycoproteins, Liver Cirrhosis, Biliary, Histocompatibility Antigens Class II, HLA-DR Antigens, Middle Aged, HLA-DQ alpha-Chains, White People, Haplotypes, Risk Factors, Case-Control Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Female, Alleles, Aged, HLA-DRB1 Chains
Adult, Membrane Glycoproteins, Liver Cirrhosis, Biliary, Histocompatibility Antigens Class II, HLA-DR Antigens, Middle Aged, HLA-DQ alpha-Chains, White People, Haplotypes, Risk Factors, Case-Control Studies, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Female, Alleles, Aged, HLA-DRB1 Chains
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