129/SvJ mice have mutated CD23 and hyper IgE
Copyright policy )129/SvJ mice have mutated CD23 and hyper IgE
CD23, the low affinity IgE receptor, is hypothesized to function as a negative regulator of IgE production. Upon discovering reduced CD23 surface levels in 129/SvJ inbred mice, we sought to further investigate 129/SvJ CD23 and to examine its influence on IgE levels. Five amino acid substitutions were found in 129/SvJ CD23. Identical mutations were also observed in CD23 from New Zealand Black and 129P1/ReJ mice. 129/SvJ B cells proliferated more rapidly than those from BALB/c after stimulation with IL-4 and CD40 ligand trimer. However, in vitro IgE levels in supernatants from stimulated 129/SvJ B cells were significantly reduced. Contrary to the in vitro findings, the 129/SvJ CD23 mutations correlated with a hyper IgE phenotype in vivo and 129/SvJ were able to clear Nippostrongylus brasiliensis infection more rapidly than either BALB/c or C57BL/6. Overall, this study further suggests that CD23 is an important regulatory factor for IgE production.
- Virginia Commonwealth University United States
Binding Sites, Receptors, IgE, Cell Membrane, Molecular Sequence Data, Mice, Inbred Strains, Immunoglobulin E, Mice, Gene Expression Regulation, Antibody Formation, Mutation, Animals, Amino Acid Sequence, RNA, Messenger, Sequence Alignment, Cells, Cultured, Conserved Sequence
Binding Sites, Receptors, IgE, Cell Membrane, Molecular Sequence Data, Mice, Inbred Strains, Immunoglobulin E, Mice, Gene Expression Regulation, Antibody Formation, Mutation, Animals, Amino Acid Sequence, RNA, Messenger, Sequence Alignment, Cells, Cultured, Conserved Sequence
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