Human-Leukocyte Antigen Class I Cw 1502 and Class II DR 0301 Genotypes Are Associated with Resistance to Severe Acute Respiratory Syndrome (SARS) Infection
Copyright policy )Human-Leukocyte Antigen Class I Cw 1502 and Class II DR 0301 Genotypes Are Associated with Resistance to Severe Acute Respiratory Syndrome (SARS) Infection
One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3 y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).
- Department of Health Taiwan
- Mackay Memorial Hospital Taiwan
- Taipei City Government Taiwan
- National Yang Ming University Taiwan
- Academia Sinica Taiwan
Adult, Male, Genotype, Histocompatibility Testing, Taiwan, HLA-C Antigens, Antibodies, Viral, Severe Acute Respiratory Syndrome, Antibodies, Neutralizing, HLA-DR3 Antigen, Asian People, Severe acute respiratory syndrome-related coronavirus, Case-Control Studies, Humans, Female, Disease Resistance
Adult, Male, Genotype, Histocompatibility Testing, Taiwan, HLA-C Antigens, Antibodies, Viral, Severe Acute Respiratory Syndrome, Antibodies, Neutralizing, HLA-DR3 Antigen, Asian People, Severe acute respiratory syndrome-related coronavirus, Case-Control Studies, Humans, Female, Disease Resistance
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