Cloning of cDNA and Genomic DNA Encoding Human Type XVIII Collagen and Localization of the α1(XVIII) Collagen Gene to Mouse Chromosome 10 and Human Chromosome 21
Copyright policy )Cloning of cDNA and Genomic DNA Encoding Human Type XVIII Collagen and Localization of the α1(XVIII) Collagen Gene to Mouse Chromosome 10 and Human Chromosome 21
Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which we have proposed the name the MULTIPLEXIN family. Members of this class contain polypeptides with multiple triple-helical domains separated and flanked by non-triple-helical regions. In this paper, we report the isolation of human cDNAs and genomic DNAs encoding the alpha 1(XVIII) collagen chain. Utilizing a genomic clone as probe, we have mapped the COL18A1 gene to chromosome 21q22.3 by fluorescence in situ hybridization. In addition, using an interspecific backcross panel, we have shown that the murine Col18a1 locus is on chromosome 10, close to the loci for Col6a1 and Col6a2.
- Duke University Health System United States
- Harvard University United States
- Duke Medical Center United States
- Duke University United States
- Duke University Hospital United States
Male, DNA, Complementary, Base Sequence, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 21, Molecular Sequence Data, DNA, Muridae, Mice, Organ Specificity, Multigene Family, Animals, Humans, Hybridization, Genetic, Female, Amino Acid Sequence, Collagen, Sequence Alignment, Crosses, Genetic, In Situ Hybridization, Fluorescence
Male, DNA, Complementary, Base Sequence, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 21, Molecular Sequence Data, DNA, Muridae, Mice, Organ Specificity, Multigene Family, Animals, Humans, Hybridization, Genetic, Female, Amino Acid Sequence, Collagen, Sequence Alignment, Crosses, Genetic, In Situ Hybridization, Fluorescence
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