Replies to comments made by H. Brazeau, G. N. Pfund, and P. L. Hill (see record 2019-81943-004) on the original article by J. K. Kiecolt-Glaser (see record 2018-62311-007). Brazeau, Pfund, and Hill's (2020) comment on Kiecolt-Glaser's (2018) "Marriage, Divorce, and the Immune System" review article provides a thoughtful application of attachment theory to the relationship-health link. In addition to an attachment perspective, we offer multiple moderating and mediating mechanisms through which marriage contributes to health. A brief overview of relationship stress and coping models, as well as the importance of couples' interdependence, is discussed. We provide specific individual, couple, and developmental-contextual factors through an interdependence lens that help explain the health costs and benefits of relationships. (PsycINFO Database Record (c) 2020 APA, all rights reserved).