Synthesis and Biological Activity of New Derivatives of 3-(3,4-Diaryl-1,2,4-triazole-5-yl)propenoic Acid.

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Oct 2004 English Publisher:WileyJournal:ChemInform, volume 36 (issn: 0931-7597, eissn: 1522-2667,

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Authors: Boźena, Modzelewska-Banachiewicz; Jacek, Banachiewicz; Anna, Chodkowska; Ewa, Jagiełło-Wójtowicz; Liliana, Mazur;

doi: 10.1002/chin.200511145 , 10.1016/j.ejmech.2004.07.002

pmid: 15464621

Synthesis and Biological Activity of New Derivatives of 3-(3,4-Diaryl-1,2,4-triazole-5-yl)propenoic Acid.

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Abstract

New 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid derivatives (8-14) were synthesized by condensation of N(3)-substituted amidrazones (1-7) with maleic anhydride. Molecular structure of obtained compounds was confirmed by an elemental analysis, IR and (1)H NMR spectra, and the X-ray crystallography for compound 11. The influence of the compound 9 on the central nervous system (CNS) of mice in some behavioural test was examined. The investigated compound showed anticonvulsive activity and potent antinociceptive action.

Related Organizations

Medical University of Lublin
Poland
Medical University of Lodz
Poland
Maria Curie-Skłodowska University
Poland

Keywords

Male, Mice, Animals, Anticonvulsants, Alkenes, Triazoles, Pain Measurement

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