<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

descriptionPublicationkeyboard_double_arrow_right Article 20 Nov 2014 English Publisher:American Society of HematologyJournal:Blood, volume 124, pages 3,260-3,273 (issn: 0006-4971, eissn: 1528-0020,

Authors: Alyssa Carey; Eduardo Firpo; Shannon K. McWeeney; Ryan MacKenzie; Michael W. Deininger; Brian J. Druker; Brian J. Druker; +12 Authors

doi: 10.1182/blood-2013-04-497040

pmid: 25293778

pmc: PMC4239335

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

- Summary
- Subjects
- Related research
  (64)
- Metrics

Abstract

Key PointsCoordinated BCR-ABL1 kinase-dependent and -independent mechanisms convert p27 from a nuclear tumor suppressor to a cytoplasmic oncogene. Oncogenic functions of p27 that persist despite effective BCR-ABL1 inhibition may contribute to resistance to tyrosine kinase inhibitors.

Related Organizations

University of Utah
United States
The University of Texas MD Anderson Cancer Center
United States
Huntsman Cancer Institute
United States
Cancer Research Center of Toulouse
France
Fred Hutchinson Cancer Research Center
South Africa

View all View all

Keywords

Oncogene Proteins, Cytoplasm, Fusion Proteins, bcr-abl, Mice, Transgenic, Mice, Inbred C57BL, Mice, Protein Transport, Cell Transformation, Neoplastic, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, Genes, Tumor Suppressor, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p27

64 Research products, page of 7

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	27
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%