Effect of Aging on the Expression of Adrenomedullin and Its Receptor Component Proteins in the Male Reproductive System of the Rat
Copyright policy )Effect of Aging on the Expression of Adrenomedullin and Its Receptor Component Proteins in the Male Reproductive System of the Rat
This study investigated the levels of adrenomedullin (AM) and the gene expression of AM, calcitonin receptor-like receptor (CRLR), receptor activity-modifying proteins (RAMPs), and receptor-coupling protein (RCP) in the testis, ventral prostate, seminal vesicle, and epididymis in rats aged 3, 12, and 20 months by radioimmunoassay and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). The results indicate an age-related increase in AM and its messenger RNA (mRNA) levels in the testis and decrease in the sex accessory glands. The gene expression of CRLR and RCP decreased only in the sex accessory glands. The changes in the gene expression of RAMPs suggest that the major increase was in CGRP receptors in the testis, whereas the major decreases in the ventral prostate and the seminal vesicles might be CGRP and AM receptors, respectively. The decreases in these receptors were similar in the epididymis. The results suggest possible roles of AM in the male reproductive system during aging.
- University of Hong Kong China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
Male, Aging, Calcitonin Gene-Related Peptide - genetics, 612, Genitalia, Male, Receptor Activity-Modifying Proteins, Rats, Sprague-Dawley, Adrenomedullin, Receptors, Genitalia, Male - chemistry - metabolism, Animals, Testosterone, Genitalia, RNA, Messenger, Adrenomedullin - analysis - genetics - physiology, Receptors, Calcitonin Gene-Related Peptide - genetics, Calcitonin Receptor-Like Protein, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Calcitonin - genetics, Male - chemistry - metabolism, Receptors, Calcitonin, Rats, Messenger - analysis, Aging - metabolism, RNA, Messenger - analysis, Receptors, Calcitonin - genetics, RNA, Sprague-Dawley, Membrane Proteins - genetics, Intracellular Signaling Peptides and Proteins - genetics, Testosterone - blood, Receptors, Calcitonin Gene-Related Peptide
Male, Aging, Calcitonin Gene-Related Peptide - genetics, 612, Genitalia, Male, Receptor Activity-Modifying Proteins, Rats, Sprague-Dawley, Adrenomedullin, Receptors, Genitalia, Male - chemistry - metabolism, Animals, Testosterone, Genitalia, RNA, Messenger, Adrenomedullin - analysis - genetics - physiology, Receptors, Calcitonin Gene-Related Peptide - genetics, Calcitonin Receptor-Like Protein, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Calcitonin - genetics, Male - chemistry - metabolism, Receptors, Calcitonin, Rats, Messenger - analysis, Aging - metabolism, RNA, Messenger - analysis, Receptors, Calcitonin - genetics, RNA, Sprague-Dawley, Membrane Proteins - genetics, Intracellular Signaling Peptides and Proteins - genetics, Testosterone - blood, Receptors, Calcitonin Gene-Related Peptide
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).10 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!