Latent TGF‐β binding protein‐3 (LTBP‐3) requires binding to TGF‐β for secretion
Copyright policy )Latent TGF‐β binding protein‐3 (LTBP‐3) requires binding to TGF‐β for secretion
Latent transforming growth factor‐β (TGF‐β) binding protein (LTBP)‐1, which is easily secreted, has been shown to enhance the secretion of TGF‐β. Here we show that another member of the LTBP family, LTBP‐3, is not secreted by several cell types, but secretion occurs after coexpression with TGF‐β. The secretion of LTBP‐3 requires complexing of LTBP‐3 with Cys33 of the TGF‐β propeptide.
- University of Chicago United States
- New York University United States
- New York University School of Medicine United States
Recombinant Fusion Proteins, Latent transforming growth factor-β binding protein, Intracellular Signaling Peptides and Proteins, Transforming growth factor-β, Transfection, Mice, Latent TGF-beta Binding Proteins, Transforming Growth Factor beta, Animals, Humans, Cysteine, Disulfides, Carrier Proteins, Cells, Cultured, Adaptor Proteins, Signal Transducing, Protein Binding
Recombinant Fusion Proteins, Latent transforming growth factor-β binding protein, Intracellular Signaling Peptides and Proteins, Transforming growth factor-β, Transfection, Mice, Latent TGF-beta Binding Proteins, Transforming Growth Factor beta, Animals, Humans, Cysteine, Disulfides, Carrier Proteins, Cells, Cultured, Adaptor Proteins, Signal Transducing, Protein Binding
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