Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance
Copyright policy )Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance
Multidrug resistance in cancer is a major obstacle for clinical therapeutics, and is the reason for 90% of treatment failures. This study investigated the efficiency of novel multifunctional Fe(3)O(4) magnetic nanoparticles (Fe(3)O(4)-MNP) combined with chemotherapy and hyperthermia for overcoming multidrug resistance in an in vivo model of leukemia.Nude mice with tumor xenografts were randomly divided into a control group, and the treatment groups were allocated to receive daunorubicin, 5-bromotetrandrine (5-BrTet) and daunorubicin, Fe(3)O(4)-MNP, and Fe(3)O(4)-MNP coloaded with daunorubicin and 5-bromotetrandrine (Fe(3)O(4)-MNP-DNR-5-BrTet), with hyperthermia in an alternating magnetic field. We investigated tumor volume and pathology, as well as P-glycoprotein, Bcl-2, Bax, and caspase-3 protein expression to elucidate the effect of multimodal treatment on overcoming multidrug resistance.Fe(3)O(4)-MNP played a role in increasing tumor temperature during hyperthermia. Tumors became significantly smaller, and apoptosis of cells was observed in both the Fe(3)O(4)-MNP and Fe(3)O(4)-MNP-DNR-5-BrTet groups, especially in the Fe(3)O(4)-MNP-DNR-5-BrTet group, while tumor volumes in the other groups had increased after treatment for 12 days. Furthermore, Fe(3)O(4)-MNP-DNR-5-BrTet with hyperthermia noticeably decreased P-glycoprotein and Bcl-2 expression, and markedly increased Bax and caspase-3 expression.Fe(3)O(4)-MNP-DNR-5-BrTet with hyperthermia may be a potential approach for reversal of multidrug resistance in the treatment of leukemia.
- Southeast University China (People's Republic of)
- Southwest University China (People's Republic of)
- Medical School Greece
- Southeast University China (People's Republic of)
Medicine (General), Magnetic Field Therapy, Mice, Nude, Antineoplastic Agents, Benzylisoquinolines, Mice, R5-920, International Journal of Nanomedicine, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Magnetite Nanoparticles, Original Research, Mice, Inbred BALB C, Caspase 3, Daunorubicin, Hyperthermia, Induced, Combined Modality Therapy, Drug Resistance, Multiple, Nanomedicine, Proto-Oncogene Proteins c-bcl-2, Drug Resistance, Neoplasm, K562 Cells
Medicine (General), Magnetic Field Therapy, Mice, Nude, Antineoplastic Agents, Benzylisoquinolines, Mice, R5-920, International Journal of Nanomedicine, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Magnetite Nanoparticles, Original Research, Mice, Inbred BALB C, Caspase 3, Daunorubicin, Hyperthermia, Induced, Combined Modality Therapy, Drug Resistance, Multiple, Nanomedicine, Proto-Oncogene Proteins c-bcl-2, Drug Resistance, Neoplasm, K562 Cells
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).67 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!