
In developing muscles in vivo and in vitro, the acetylcholine receptor γ-subunit exists in two splice variants, conferring different single-channel open durations (τop) to reconstituted receptors. In mouse muscles, τop changes around birth, possibly as receptors incorporate either variant of γ-subunit. This might be relevant to the concomitant maturation of muscle innervation.
acetylcholine receptor; alternative splicing; kinetic properties; muscle development
acetylcholine receptor; alternative splicing; kinetic properties; muscle development
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