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Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Feb 2021 Belgium, United States, United States English Publisher:Elsevier BVJournal:JACC: Basic to Translational Science, volume 6, pages 89-99 (issn: 2452-302X,

Copyright policy )Funded by:NIH | Management of hypertensio..., NIH | Developing Oral LT3 Thera..., NIH | Subclinical Vascular Cont... +6 projects

Authors: Hanff, Thomas C.; Cohen, Jordana B.; Zhao, Lei; Javaheri, Ali; Zamani, Payman; Prenner, Stuart B.; Rietzschel, Ernst; +12 Authors

doi: 10.1016/j.jacbts.2020.11.011

pmid: 33665511

pmc: PMC7907637

handle: 1854/LU-01GJYY1R2PPH1SHAFHPF50B5XZ

Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

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Abstract

Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI: 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization.

Countries

Belgium, United States, United States

Related Organizations

Washington State University
United States
Ghent University
Belgium
Bristol-Myers Squibb (United States)
United States
Washington University in St. Louis
United States
University of Mary
United States

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Keywords

proteomics, diabetes, Clinical Research, Medicine and Health Sciences, apolipoprotein M, heart failure, mediation analysis

10 Research products, page 1 of 1

Ubiquitin-conjugating enzyme E2 G2
2017IsRelatedTo
Fatty acid-binding protein, heart
2017IsRelatedTo
Tumor necrosis factor ligand superfamily member 15
2017IsRelatedTo
Reticulon-4 receptor
2017IsRelatedTo
Trafficking protein particle complex subunit 3
2017IsRelatedTo
Apolipoprotein M
2017IsRelatedTo
Pigment epithelium-derived factor
2017IsRelatedTo
Q8IUL8
2017IsRelatedTo
Protein AMBP
2017IsRelatedTo
Insulin
2017IsRelatedTo

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	25
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%