Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases
Copyright policy )Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases
The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy. The Val/Val genotype tended to show elevated alanine aminotransferase levels (odds ratio=3.5; P=0.056). In addition, an elevated γ-glutamyltransferase level was associated with the Val/Val genotype (odds ratio=3.1; P=0.022). The SOD2 Val/Val genotype may therefore contribute to a valproic acid-induced elevation in the serum aminotransferase levels.
- Hamamatsu University School of Medicine Japan
- Kumamoto University Japan
- Hirosaki University Japan
Adult, Male, Alanine, Epilepsy, Polymorphism, Genetic, Adolescent, Superoxide Dismutase, Valproic Acid, Infant, Valine, Middle Aged, Young Adult, Risk Factors, Child, Preschool, Humans, Female, Child, Transaminases, Aged
Adult, Male, Alanine, Epilepsy, Polymorphism, Genetic, Adolescent, Superoxide Dismutase, Valproic Acid, Infant, Valine, Middle Aged, Young Adult, Risk Factors, Child, Preschool, Humans, Female, Child, Transaminases, Aged
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