Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.
Copyright policy )Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.
We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.
- California Institute of Technology United States
570, Mice, Inbred BALB C, Membrane Glycoproteins, Polymorphism, Genetic, Base Sequence, Genetic Linkage, Gene Conversion, Chromosome Mapping, DNA, Major Histocompatibility Complex, Mice, Genes, Antigens, Neoplasm, Animals, Amino Acid Sequence, Chromosome Deletion, Cloning, Molecular, Alleles
570, Mice, Inbred BALB C, Membrane Glycoproteins, Polymorphism, Genetic, Base Sequence, Genetic Linkage, Gene Conversion, Chromosome Mapping, DNA, Major Histocompatibility Complex, Mice, Genes, Antigens, Neoplasm, Animals, Amino Acid Sequence, Chromosome Deletion, Cloning, Molecular, Alleles
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