Glia instruct developmental neuronal remodeling through TGF-β signaling
Copyright policy )Glia instruct developmental neuronal remodeling through TGF-β signaling
We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
- University of Minnesota Morris United States
- University of Massachusetts System United States
- University of Minnesota Crookston United States
- University of Minnesota United States
- University of Minnesota United States
*Models, Neurogenesis, Green Fluorescent Proteins, Models, Neurological, Genetically Modified, Article, Animals, Genetically Modified, Double-Stranded, Transforming Growth Factor beta, Animals, Drosophila Proteins, Developmental, Mushroom Bodies, RNA, Double-Stranded, Neuroscience and Neurobiology, Gene Expression Regulation, Developmental, MicroRNAs, Gene Expression Regulation, Neurological, Mutation, RNA, Drosophila, Neuroglia, Signal Transduction
*Models, Neurogenesis, Green Fluorescent Proteins, Models, Neurological, Genetically Modified, Article, Animals, Genetically Modified, Double-Stranded, Transforming Growth Factor beta, Animals, Drosophila Proteins, Developmental, Mushroom Bodies, RNA, Double-Stranded, Neuroscience and Neurobiology, Gene Expression Regulation, Developmental, MicroRNAs, Gene Expression Regulation, Neurological, Mutation, RNA, Drosophila, Neuroglia, Signal Transduction
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