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doi: 10.1007/bf00364657
pmid: 8422497
We present here the genetic mapping of the alpha-skeletal actin locus (Actsk-1) on mouse Chromosome (Chr) 8, on the basis of the PCR analysis of a microsatellite in an interspecific backcross. Linkage and genetic distances were established for four loci by analysis of 192 (or 222) meiotic events and indicated the following gene order: (centromere)-Es-1-11.7 cM-Tat-8.3 cM-Actsk-1-0.5 cM-Aprt. Mapping of ACTSK to human Chr 1 and of TAT and APRT to human Chr 16 demonstrates the existence of a new short region of homology between mouse Chr 8 and human Chr 1. Intermingling on this scale between human and mouse chromosomal homologies that occurred during evolution creates disorders in comparative linkage studies.
Base Sequence, Molecular Sequence Data, Adenine Phosphoribosyltransferase, Chromosome Mapping, Mice, Inbred Strains, DNA, Satellite, Hybrid Cells, Polymerase Chain Reaction, Actins, Mice, Chromosomes, Human, Pair 1, Animals, Humans, Chromosomes, Human, Pair 16
Base Sequence, Molecular Sequence Data, Adenine Phosphoribosyltransferase, Chromosome Mapping, Mice, Inbred Strains, DNA, Satellite, Hybrid Cells, Polymerase Chain Reaction, Actins, Mice, Chromosomes, Human, Pair 1, Animals, Humans, Chromosomes, Human, Pair 16
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