Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ
Copyright policy )Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ
Innate immune responses are crucial for host defense against pathogens, but need to be tightly regulated to prevent chronic inflammation. Initial characterization of mice with a targeted inactivating mutation in the p110d subunit of phosphoinositide 3-kinase (PI3K p110δD910A/D910A) reveal defects in B- and T-cell signaling and chronic colitis. Here, we further characterize features of inflammatory bowel diseases (IBD) in these mice and investigate underlying innate immune defects.
- University of North Carolina at Chapel Hill United States
- University of Pennsylvania United States
- University of Pittsburgh United States
- Queen Mary University of London United Kingdom
Colon, Macrophages, Gene Expression, Enzyme-Linked Immunosorbent Assay, Colitis, Polymerase Chain Reaction, Immunity, Innate, Mice, Inbred C57BL, Disease Models, Animal, Mice, Chronic Disease, Disease Progression, Animals, RNA, Phosphatidylinositol 3-Kinase
Colon, Macrophages, Gene Expression, Enzyme-Linked Immunosorbent Assay, Colitis, Polymerase Chain Reaction, Immunity, Innate, Mice, Inbred C57BL, Disease Models, Animal, Mice, Chronic Disease, Disease Progression, Animals, RNA, Phosphatidylinositol 3-Kinase
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