Progranulin compensates for blocked IGF‐1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway
Copyright policy )Progranulin compensates for blocked IGF‐1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway
It is well known that growth hormone (GH)‐induced IGF‐1 signaling plays a dominant role in postnatal muscle growth. Our previous studies have identified a growth factor, progranulin (PGRN), that is co‐induced with IGF‐1 upon GH administration. This result prompted us to explore the function of PGRN and its association with IGF‐1. In the present study, we demonstrated that, similar to IGF‐1, PGRN can promote C2C12 myotube hypertrophy via the PI(3)K/Akt/mTOR pathway. Moreover, PGRN can rescue the muscle atrophy phenotypes in C2C12 myotube when IGF‐1 signaling is blocked. This result shows that PGRN can substitute for IGF‐1 signaling in the regulation of muscle growth. Our findings provide new insights into IGF‐1‐modulated complicated networks that regulate muscle growth.
Progranulin, Muscle Fibers, Skeletal, Muscle Development, Models, Biological, Cell Line, Myoblasts, Mice, Phosphatidylinositol 3-Kinases, Progranulins, Animals, RNA, Messenger, Insulin-Like Growth Factor I, DNA Primers, Granulins, Base Sequence, TOR Serine-Threonine Kinases, Hypertrophy, Signaling, Muscular Atrophy, IGF-1, Intercellular Signaling Peptides and Proteins, Muscle hypertrophy, C2C12 myoblast, Proto-Oncogene Proteins c-akt, Signal Transduction
Progranulin, Muscle Fibers, Skeletal, Muscle Development, Models, Biological, Cell Line, Myoblasts, Mice, Phosphatidylinositol 3-Kinases, Progranulins, Animals, RNA, Messenger, Insulin-Like Growth Factor I, DNA Primers, Granulins, Base Sequence, TOR Serine-Threonine Kinases, Hypertrophy, Signaling, Muscular Atrophy, IGF-1, Intercellular Signaling Peptides and Proteins, Muscle hypertrophy, C2C12 myoblast, Proto-Oncogene Proteins c-akt, Signal Transduction
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