Objectives Little is known about ventricular function in OSHAS (obstructive sleep apnoea hypopnoea syndrome) patients without clinical symptoms of cardiovascular disease. The aims of this study was therefore to evaluate whether dobutamine stress 99mTc-tetrofosmin quantitative gated SPECT (QGS) could find early cardiovascular complications. Methods The study included 29 OSAHS patients and 10 normal subjects with the resting electrocardiogram and echocardiography unremarkable. 29 OSAS patients were classified into three groups according to their apnoea-hypopnea index (AHI). QGS was performed in all subjects at rest and during dobutamine infusion (20 µg/kg/min). The left ventricular ejection fraction (LVEF), peak ejection rate (PER), peak filling rate (PFR), 1/3 filling rate (1/3FR) and regional ejection fraction values were calculated for each subject. Results Compared with the control group in the dobutamine stress QGS, the LVEF (Left ventricular ejection fraction), PER (Peak ejection rate),1/3FR (1/3 peak filling rate) and PFR (Peak filling rate) were significantly different (53.77±6.11 vs 61.61±5.42, 4.33±1.04 vs 7.34±1.14, 3.47±0.82 vs 5.90±1.23, 3.14±1.42 vs 6.12±1.24; p 2 min (lowest oxygen saturation at night) (p Conclusions The positive rate of damaged cardiac function is more than 50% in the severe group compared with the normal control group by performing D-QGS. These findings indicate that D-QGS can be used to predict early cardiovascular complications in OSHAS patients with the resting electrocardiogram and echocardiography unremarkable.