Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia
Copyright policy )Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia
Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.
- Stony Brook University United States
Brain Chemistry, Mammals, DNA, Complementary, Ganglia, Sympathetic, Potassium Channels, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression, Sciatic Nerve, Ether-A-Go-Go Potassium Channels, Rats, DNA-Binding Proteins, Xenopus laevis, Proto-Oncogene Proteins, Animals, RNA, Messenger, Cloning, Molecular, Transcription Factors, ets-Domain Protein Elk-1
Brain Chemistry, Mammals, DNA, Complementary, Ganglia, Sympathetic, Potassium Channels, Sequence Homology, Amino Acid, Molecular Sequence Data, Gene Expression, Sciatic Nerve, Ether-A-Go-Go Potassium Channels, Rats, DNA-Binding Proteins, Xenopus laevis, Proto-Oncogene Proteins, Animals, RNA, Messenger, Cloning, Molecular, Transcription Factors, ets-Domain Protein Elk-1
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