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Nature Immunology
Article . 2011 . Peer-reviewed
License: Springer TDM
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Nature Immunology
Article . 2011
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Nature Immunology
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The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

descriptionPublicationkeyboard_double_arrow_right Article 03 Apr 2011 English Publisher:Springer Science and Business Media LLCJournal:Nature Immunology, volume 12, pages 450-459 (issn: 1529-2908, eissn: 1529-2916, Copyright policy )
Authors: Hiroshi Kitamura; Koichiro Matsumoto; Jinfang Zhu; Koji Atarashi; Masaru Taniguchi; Yasutaka Motomura; Hiroshi Watarai; +5 Authors

doi: 10.1038/ni.2020

pmid: 21460847

pmc: PMC3494493

The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells

Abstract

The immunoregulatory cytokine interleukin 10 (IL-10) is expressed mainly by T helper type 2 (T(H)2) cells but also by T(H)1 cells during chronic infection. Here we observed plasticity in the expression of IL-10 and IL-13 after chronic T(H)1 stimulation; furthermore, the expression of Il10 and Il13 was regulated by the transcription factor E4BP4. Chronically stimulated E4BP4-deficient (Nfil3(-/-); called 'E4bp4(-/-)' here) T(H)1 cells, regulatory T cells (T(reg) cells) and natural killer T cells (NKT cells) had attenuated expression of IL-10 and IL-13. Enforced expression of E4bp4 initiated the production of IL-10 and IL-13 by conventional T(H)1 cells. E4bp4(-/-) T(H)2 cells showed impairment of IL-10 production with no effect on IL-13. Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T(H)1 cells and IL-10 in T(H)1 cells, T(H)2 cells, T(reg) cells and NKT cells.

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Keywords

CD4-Positive T-Lymphocytes, Mice, Knockout, Mice, Inbred BALB C, Interleukin-13, Transcription, Genetic, Electrophoretic Mobility Shift Assay, Mice, Transgenic, Flow Cytometry, Autoimmune Diseases, Interleukin-10, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, Mice, Basic-Leucine Zipper Transcription Factors, Animals, Promoter Regions, Genetic

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 181
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
181
Top 1%
Top 10%
Top 1%
bronze