Co-localization of FGF-2 and a novel heparan sulphate proteoglycan in embryonic mouse brain
Copyright policy )Co-localization of FGF-2 and a novel heparan sulphate proteoglycan in embryonic mouse brain
Neural precursor cells are known to be greatly stimulated during their development by members of the fibroblast growth factor (FGF) family of growth factors. FGF activity is regulated by essential interactions with a low affinity class of receptors called heparan sulphate proteoglycans (HSPGs), which modulate subsequent binding to the high affinity signal transducing receptors. We have purified a novel species of secreted HSPG and generated specific polyclonal antibodies against its core protein. The HSPG exactly co-localizes with FGF-2 within the neuroepithelium of the embryonic mouse. The results support the concept that HSPGs play crucial roles in regulating neural cell responses to particular growth factors.
- University of Melbourne Australia
- University of Queensland Australia
- University of Queensland Australia
- Walter and Eliza Hall Institute of Medical Research Australia
- Royal Melbourne Hospital Australia
571, Fibroblast Growth Factor, Nerve Tissue Proteins, Adhesion Molecule, Mice, Heparan Sulfate Proteoglycan, Animals, Glycosaminoglycans, Brain Chemistry, Fibroblast Growth-Factor, Brain, Binding, Sulfate, Extracellular Matrix, Fibroblast Growth Factors, Differentiation, Stimulation, Neural Precursor Cells, Mice, Inbred CBA, Proteoglycans, Heparitin Sulfate, Neuroepithelium, Heparan Sulfate Proteoglycans
571, Fibroblast Growth Factor, Nerve Tissue Proteins, Adhesion Molecule, Mice, Heparan Sulfate Proteoglycan, Animals, Glycosaminoglycans, Brain Chemistry, Fibroblast Growth-Factor, Brain, Binding, Sulfate, Extracellular Matrix, Fibroblast Growth Factors, Differentiation, Stimulation, Neural Precursor Cells, Mice, Inbred CBA, Proteoglycans, Heparitin Sulfate, Neuroepithelium, Heparan Sulfate Proteoglycans
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