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Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

descriptionPublicationkeyboard_double_arrow_right Article 16 Nov 2012 English Publisher:American Society of HematologyJournal:Blood, volume 121, pages 1,094-1,101 (issn: 0006-4971, eissn: 1528-0020, Copyright policy )
Authors: Yuan Gao; Diane S. Krause; Elenoe C. Smith; Lin Wang; Katherine L. Hahn; Alexandra M. Teixeira; Rachel C. Chen;

doi: 10.1182/blood-2012-05-429993 , 10.1182/blood.v120.21.3440.3440

pmid: 23243284

pmc: PMC3575755

Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

Abstract

Key Points RhoA-induced actin polymerization promotes nuclear accumulation of MKL1 and transcriptional activation. Thrombopoietin activates nuclear accumulation of MKL1 and transcriptional activation in primary megakarocytes.

Related Organizations
Keywords

Cell Nucleus, Serum Response Factor, Oncogene Proteins, Fusion, Cell Differentiation, Actins, DNA-Binding Proteins, Enzyme Activation, Mice, Thrombopoietin, Cell Line, Tumor, Trans-Activators, Animals, Humans, Tetradecanoylphorbol Acetate, Protein Multimerization, rhoA GTP-Binding Protein, Megakaryocytes, Megakaryocyte Progenitor Cells

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 43
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Top 10%
Top 10%
Top 10%
bronze