Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes
Copyright policy )Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes
Abstract mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes. In the present study, individual breast cancer cell clones displaying low vs. high uPAR-del4/5 expression were analyzed demonstrating that uPAR-del4/5 leads to reduced cell adhesion and invasion in a dose-dependent manner. Additionally, matrix metalloproteinase-9 (MMP-9) was found to be strongly upregulated in uPAR-del4/5 overexpressing compared to vector control cells. uPAR-del4/5 may thus play an important role in the regulation of the extracellular proteolytic network and, by this, influence the metastatic potential of breast cancer cells.
- Technical University of Munich Germany
- Ludwig-Maximilians-Universität München Germany
- Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten Germany
- Pathologisches Institut Germany
- TU Dresden Germany
RNA Splicing, Breast Neoplasms, Receptors, Urokinase Plasminogen Activator, Up-Regulation, Gene Expression Regulation, Neoplastic, Matrix Metalloproteinase 9, Cell Line, Tumor, Cell Adhesion, Humans, Female, Neoplasm Invasiveness, Breast, ddc: ddc:
RNA Splicing, Breast Neoplasms, Receptors, Urokinase Plasminogen Activator, Up-Regulation, Gene Expression Regulation, Neoplastic, Matrix Metalloproteinase 9, Cell Line, Tumor, Cell Adhesion, Humans, Female, Neoplasm Invasiveness, Breast, ddc: ddc:
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