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pmid: 16546077
Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have unveiled the existence of surveillance mechanisms or checkpoints that couple the formation and repair of DSBs to cell cycle progression. Through these mechanisms, aberrant meiocytes are delayed in their meiotic progression, thereby facilitating repair of meiotic DSBs, or are culled through programmed cell death, thereby protecting the germline from aneuploidies that could lead to spontaneous abortions, birth defects and cancer predisposition in the offspring. Here we summarize recent progress in our understanding of these checkpoints. This review focuses on the surveillance mechanisms of the budding yeast S. cerevisiae, where the molecular details are best understood, but will frequently compare and contrast these mechanisms with observations in other organisms.
Recombination, Genetic, Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), DNA Repair, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, Apoptosis, Chromosome Breakage, Saccharomyces cerevisiae, Adaptation, Physiological, DNA-Binding Proteins, Chromosome Pairing, Meiosis, Mice, Animals
Recombination, Genetic, Saccharomyces cerevisiae Proteins, Agricultural and Biological Sciences(all), DNA Repair, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, Apoptosis, Chromosome Breakage, Saccharomyces cerevisiae, Adaptation, Physiological, DNA-Binding Proteins, Chromosome Pairing, Meiosis, Mice, Animals
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 128 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 10% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 1% |