Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice
Copyright policy )Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice
Ikaros and Notch1 genes are critical to T-cell differentiation through transcriptional activation of target genes and interaction with chromatin remodeling complexes. An Ikaros (Plastic) point mutation inhibits activity of normal Ikaros and Ikaros family members, and leads to T-cell lymphoma in heterozygotes (Plstc/+). Analysis revealed Notch1 activating mutations in 12 of 17 Plstc/+ lymphomas (70%), analogous to those in human T-ALL. Mice acquired Notch1 mutations in lymph nodes as early as 7 weeks. Thus, combined Notch1 and Ikaros dysfunction can be a significant early event in T-cell proliferation and tumorigenesis.
- Columbia University United States
- King’s University United States
Male, Transcriptional Activation, Heterozygote, DNA Mutational Analysis, Cell Differentiation, Mice, Transgenic, Lymphoma, T-Cell, Mice, Inbred C57BL, Ikaros Transcription Factor, Mice, Cell Transformation, Neoplastic, Animals, Humans, Point Mutation, Female, Receptor, Notch1, Cell Proliferation
Male, Transcriptional Activation, Heterozygote, DNA Mutational Analysis, Cell Differentiation, Mice, Transgenic, Lymphoma, T-Cell, Mice, Inbred C57BL, Ikaros Transcription Factor, Mice, Cell Transformation, Neoplastic, Animals, Humans, Point Mutation, Female, Receptor, Notch1, Cell Proliferation
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