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Efektivitas Suspensi Ekstrak Etanol Umbi Bawang Putih (Allium sativum L.) Sebagai Diuretik Pada Tikus Putih Jantan (Rattus norvegicus)

Authors: Selvi Marcellia; Dewi Chusniasih; Aprilia Andansari;

Efektivitas Suspensi Ekstrak Etanol Umbi Bawang Putih (Allium sativum L.) Sebagai Diuretik Pada Tikus Putih Jantan (Rattus norvegicus)

Abstract

Garlic (Allium sativum L.) contains phallovonoids and alkaloids, which have a mild effect on urine. However, it has not been scientifically proven. This research aims to determine the effectiveness of garlic ethanol extract (Allium sativum L.) as a diuretic in Sprague dawley male white rats and to determine the optimum dose of garlic ethanol extract 96% as a diuretic. This experiment was carried out on 20 rats divided into five groups, each group consists of 4 rats. Groups I, II, III received garlic extract with a concentration of 25mg/KgBW; 35mg/KgBW and 45mg/KgBW, while group IV received 0.5% Na.CMC as a negative control and group V as a positive control received furosemide at a dose of 20mg/kgBW. Based on the results, each treatment group I, II, III, IV, and V obtained an average urine volume value of 2.95 ml, 3.27 ml, 3.76 ml, 2.3 ml, 4. 57 ml. Therefore, it was concluded that all the treatment groups using garlic extract suspension were able to increase urine volume more than the control, in which the optimal dose of garlic extract suspension was 45 mg/kgBW, but the effect was smaller compared to furosemide (p <0.05). Keywords : Garlic Extract, Allium sativum, Diuretic, Suspension, Ethanol Bawang putih ( Allium sativum L. ) memiliki kandungan falovonoid dan alkaloid, yang diduga mampu memberikan efek pelancar kemih, namun hal ini masih perlu dibuktikan secara ilmiah. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol bawang putih ( Allium sativum L .) sebagai diuretik pada hewan tikus putih jantan galur Sprague dawley dan untuk mengetahui dosis optimum ekstrak etanol 96% bawang putih yang berkhasiat sebagai diuretik. Percobaan ini dilakukan terhadap 20 ekor tikus yang dibagi menjadi lima kelompok tiap kelompok terdiri dari 4 ekor tikus. Kelompok I, II, III diberikan ekstrak bawang putih dengan konsentrasi 25mg/KgBB; 35mg/KgBB dan 45mg/KgBB, sedangkan kelompok IV sebagai kontrol negatif diberikan Na.CMC 0,5 % dan kelompok V sebagai kontrol positif diberikan furosemid dengan dosis 20mg/kgBB. Dari hasil penelitian masing-masing kelompok perlakuan I, II, III, IV, dan V didapat nilai rata-rata volume urin yaitu 2,95 ml, 3,27 ml, 3,76 ml, 2,3 ml, 4,57 ml. Sehingga dapat disimpulkan semua kelompok perlakuan yang menggunakan suspensi ekstrak bawang putih mampu meningkatkan volume urin lebih besar dari kontrol dimana dosis optimal suspensi ekstrak bawang putih adalah 45 mg/kgBB namun efeknya masih lebih kecil jika dibandingkan dengan furosemid (p<0,05) Kata kunci : Ekstrak Bawang Putih, Allium sativum , Diuretik, Suspensi, Etanol

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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