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Annals of the New York Academy of Sciences
Article . 2008 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
Annals of the New York Academy of Sciences
Article . 2009
Data sources: Europe PubMed Central
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Congenic Mapping of the MHC‐Linked Susceptibility to Type 1 Diabetes in the NOD Mouse

At Least Two Genes Contribute to the Idd16 Effect
descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2008 English Publisher:WileyJournal:Annals of the New York Academy of Sciences, volume 1,150, pages 90-92 (issn: 0077-8923, eissn: 1749-6632, Copyright policy )
Authors: Yoshihisa, Hiromine; Tomomi, Fujisawa; Shinsuke, Noso; Naru, Babaya; Yumiko, Kawabata; Hiroshi, Ikegami;

doi: 10.1196/annals.1447.019

pmid: 19120274

Congenic Mapping of the MHC‐Linked Susceptibility to Type 1 Diabetes in the NOD Mouse

Abstract

Major histocompatibility complex (MHC)‐linked susceptibility to type 1 diabetes consists of multiple components. Previous studies with NOD mice congenic for the MHC from a sister strain, the CTS mouse, mapped Idd16, a second component of MHC‐linked susceptibility to type 1 diabetes, in the region adjacent to, but distinct from Idd1 in the class II region. In this study, three lines of subcongenic strains were established from the original congenic strain. Phenotypic analysis of the strains indicated that MHC‐linked susceptibility to type 1 diabetes consists of at least three components: Idd1, Idd16.2 adjacent to Idd1, and Idd16.1 telomeric to Idd16.2.

Related Organizations
Keywords

Genes, MHC Class II, Chromosome Mapping, Epistasis, Genetic, Chromosomes, Mice, Mice, Congenic, Diabetes Mellitus, Type 1, Genes, Mice, Inbred NOD, Animals, Female, Genetic Predisposition to Disease

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
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