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Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

descriptionPublicationkeyboard_double_arrow_right Article 08 Mar 2010 English Publisher:American Chemical Society (ACS)Journal:ACS Chemical Neuroscience, volume 1, pages 411-419 (issn: 1948-7193, eissn: 1948-7193, Copyright policy )
Authors: Williams, Richard; Zhou, Y.; Niswender, C.M.; Luo, Q.; Conn, P.J.; Lindsley, C.W.; Hopkins, C.R.;

doi: 10.1021/cn9000318

pmid: 20582156

pmc: PMC2889702

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

Abstract

This Letter describes a detailed SAR analysis of the mGluR4 positive allosteric modulator, PHCCC. We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.

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name=Physiology, /dk/atira/pure/subjectarea/asjc/1300/1303, /dk/atira/pure/subjectarea/asjc/1300/1314, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/2800/2805, 540, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cognitive Neuroscience, name=Cell Biology

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
49
Top 10%
Top 10%
Top 10%
bronze
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