This study focuses on influence of alloying content and type of manufacturing on the effectiveness of deep cryogenic treatment (DCT) on properties of selected high-alloyed ferrous alloys (HAFA): EN HS6-5-2, EN HS6-5-2-5, EN HS6-5-3 and EN HS12-1-4. In order to evaluate the dependency of DCT performance on chemical composition and manufacturing type, the microstructure, hardness, impact and fracture toughness and fatigue properties were analyzed. Additionally, the fatigue data was evaluated using an adapted strain-life model in order to understand the unique effects of DCT with selected factors and provide a model for estimating the fatigue limit of DCT HAFA. The study indicates that DCT affects carbide precipitation, size and morphology of nanocarbides, average distance between carbides and nanocarbides, as well as the base matrix (martensitic laths). The induced microstructural changes cause an overall positive change of mechanical properties in selected HAFA, which correlates well with individual alloying and manufacturing differences. Overall, DCT has greater effect on wrought HAFA than powder metallurgy manufactured HAFA, at which high content of W and Co generally degenerates the DCT induced microstructure modifications.