The Equivalent Bronchodilator Effects of Salbutamol Formulated in Chlorofluorocarbon and Hydrofluoroalkane-134a Metered Dose Inhalers on the Histamine-Induced Pulmonary Response in Dogs

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1997 English Publisher:Springer Science and Business Media LLCJournal:Pharmaceutical Research, volume 14, pages 208-212 (issn: 0724-8741, eissn: 1573-904X,

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Authors: M, Nogami-Itoh; I, Yakuo; D M, Hammerbeck; R L, Miller; K, Takeyama;

doi: 10.1023/a:1012056928780

pmid: 9090711

The Equivalent Bronchodilator Effects of Salbutamol Formulated in Chlorofluorocarbon and Hydrofluoroalkane-134a Metered Dose Inhalers on the Histamine-Induced Pulmonary Response in Dogs

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Abstract

The bronchodilator effect of salbutamol formulated in hydrofluoroalkane-134a (HFA-134a), a chlorofluorocarbon (CFC)-free propellant for metered dose inhalation (MDI) devices, was compared with that of salbutamol formulated in CFC in anesthetized dogs.Bronchospasms were induced by the intravenous injection of histamine, and bronchial resistance was measured by the method of Konzett and Rossler.While the placebo vehicles (HFA-134a and CFC propellants) had no significant effect on histamine-induced bronchospasms, the salbutamol/HFA-134a and salbutamol/CFC MDI formulations had equivalent dose-related inhibitory effects.These data indicated that salbutamol formulated in HFA-134a and that in CFC propellant are bioequivalent.

Keywords

Male, Hydrocarbons, Fluorinated, Bronchoconstriction, Nebulizers and Vaporizers, Blood Pressure, Bronchodilator Agents, Dogs, Therapeutic Equivalency, Heart Rate, Animals, Albuterol, Chlorofluorocarbons, Histamine

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