Polyamine Concentrations in the Brain of Vitamin B12-Deficient Rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2003 English Publisher:Frontiers Media SAJournal:Experimental Biology and Medicine, volume 228, pages 1,069-1,071 (issn: 1535-3702, eissn: 1535-3699,

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Authors: Koshin, Adachi; Masayuki, Izumi; Yutaka, Osano; Naofumi, Miura; Shinobu, Takatsu; Shin-Ichi, Terao; Terunori, Mitsuma;

doi: 10.1177/153537020322800913

pmid: 14530517

Polyamine Concentrations in the Brain of Vitamin B12-Deficient Rats

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Abstract

To study the pathophysiology of the neuronal degeneration in vitamin B12 deficiency, we investigated the concentrations of the polyamines putrescine, spermidine, and spermine in brain regions and liver using high-performance liquid chromatography with fluorescence detection. Male Wistar rats were fed either a control or vitamin B12-deficient diet for 20 weeks. No remarkable behavioral changes were observed. Serum vitamin B12 and hepatic methionine concentrations were significantly lower and hepatic homocysteine was elevated in rats fed vitamin B12-deficient diet than in controls. Vitamin B12 deficiency was associated with decreased concentrations of spermidine, spermidine in liver and some regions of brain, although there were no observed abnormalities in behavior. These results suggest that vitamin B12 deficiency may play a role in neuronal degeneration through the disturbance of polyamine concentrations in rat brain.

Related Organizations

Aichi Medical University
Japan

Keywords

Male, Neurons, Spermidine, Brain, Vitamin B 12 Deficiency, Rats, Vitamin B 12, Methionine, Liver, Polyamines, Putrescine, Animals, Spermine, Rats, Wistar, Homocysteine

16 Research products, page 1 of 2

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