The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients
Copyright policy )The Impact of Heat Shock Protein 70 Gene Variations on Clinical Presentation and Outcome in Schizophrenic Inpatients
We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins <i>(HSPA1A, HSPA1B</i> and <i>HSPA1L)</i> and found a significant association between one <i>HSPA1B</i> variation and schizophrenia (SZ). We now report an association between a set of variations (rs2227956, rs2075799, rs1043618, rs562047 and rs539689) within the same genes and a larger sample of schizophrenic inpatients. A single variation, rs539689 <i>(HSPA1B),</i> was found to be marginally associated with Positive and Negative Syndrome Scale (PANSS) positive scores at discharge, and haplotype analysis revealed a significant association between improvement in PANSS scores with both A-C-G-G and A-C-G-G haplotypes. These findings further support a role of heat shock proteins in the pathophysiology of SZ.
- Duke University Hospital United States
- Alma Mater Studiorum University of Bologna Italy
- Catholic University of Korea Korea (Republic of)
- Duke Medical Center United States
Adult, Male, Psychiatric Status Rating Scales, Analysis of Variance, DNA Mutational Analysis, Prognosis, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Hospitalization, Haplotypes, Multivariate Analysis, Mutation, Schizophrenia, Humans, Female, HSP70 Heat-Shock Proteins, Age of Onset
Adult, Male, Psychiatric Status Rating Scales, Analysis of Variance, DNA Mutational Analysis, Prognosis, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Hospitalization, Haplotypes, Multivariate Analysis, Mutation, Schizophrenia, Humans, Female, HSP70 Heat-Shock Proteins, Age of Onset
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