Yin yang 1 directly regulates the transcription of RE‐1 silencing transcription factor
Copyright policy )Yin yang 1 directly regulates the transcription of RE‐1 silencing transcription factor
AbstractThe RE‐1 silencing transcription factor (REST) is a master transcription factor that plays a critical role in embryo development, especially during the process of neurogenesis and neural plasticity. However, the mechanism of REST gene transcription regulation is still an open question. Here, by combining bioinformatics analysis and experimental studies, we report that the transcription factor Yin Yang 1 (YY1) bound to a conserved YY1 binding site in the promoter of the mouse REST gene and positively regulated activity of this promoter in SH‐SY5Y cells. Furthermore, analysis of microarray data revealed a significant correlation between the expression of YY1 and REST genes. Overall, this study suggests that YY1 directly regulates expression of the REST gene. © 2007 Wiley‐Liss, Inc.
- Tongji University China (People's Republic of)
- Center for Excellence in Molecular Cell Science China (People's Republic of)
- University of Hong Kong (香港大學) China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
- University of Hong Kong China (People's Republic of)
Functional binding site, Base Sequence, Transcription, Genetic, Mouse rest promoter, Molecular Sequence Data, Gene Expression Regulation, Developmental, Electrophoretic Mobility Shift Assay, Ying yang 1 (yy1), Transfection, Polymerase Chain Reaction, Re-1 silencing transcription factor (rest), Cell Line, Repressor Proteins, Mice, Re 1 silencing transcription factor, Animals, Humans, YY1 Transcription Factor, Oligonucleotide Array Sequence Analysis, Transcription Factors
Functional binding site, Base Sequence, Transcription, Genetic, Mouse rest promoter, Molecular Sequence Data, Gene Expression Regulation, Developmental, Electrophoretic Mobility Shift Assay, Ying yang 1 (yy1), Transfection, Polymerase Chain Reaction, Re-1 silencing transcription factor (rest), Cell Line, Repressor Proteins, Mice, Re 1 silencing transcription factor, Animals, Humans, YY1 Transcription Factor, Oligonucleotide Array Sequence Analysis, Transcription Factors
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