DNA methylation imprints on the IG‐DMR of theDlk1–Gtl2domain in mouse male germline
Copyright policy )DNA methylation imprints on the IG‐DMR of theDlk1–Gtl2domain in mouse male germline
Mouse genomes show a large cluster of imprinted genes at theDlk1–Gtl2domain in the distal region of chromosome 12. An intergenic‐differentially methylated region (IG‐DMR) located betweenDlk1andGtl2is specifically methylated in the male germline; IG‐DMR regulates the parental allele‐specific expression of imprinted genes. Here, we show the resetting of IG‐DMR methylation marks during male germ‐cell differentiation. For parental allele‐specific methylation analysis, polymorphisms were detected in a 2.6‐kb IG‐DMR in three mouse strains. Bisulfite methylation analysis showed erasure of the marks by E14 and re‐establishment before birth. The IG‐DMR methylation status was maintained in spermatogonia and spermatocytes of mature testes. The IG‐DMR methylation status established before birth is thus maintained throughout the lifetime in the male germline.
Male, Polymorphism, Genetic, Genomic imprinting, Mouse, DMR, Calcium-Binding Proteins, Proteins, Cell Differentiation, DNA Methylation, Methylation, Spermatozoa, Chromosomes, Cell Line, Genomic Imprinting, Mice, Germ cells, Oocytes, Animals, Intercellular Signaling Peptides and Proteins, DNA, Intergenic, RNA, Long Noncoding
Male, Polymorphism, Genetic, Genomic imprinting, Mouse, DMR, Calcium-Binding Proteins, Proteins, Cell Differentiation, DNA Methylation, Methylation, Spermatozoa, Chromosomes, Cell Line, Genomic Imprinting, Mice, Germ cells, Oocytes, Animals, Intercellular Signaling Peptides and Proteins, DNA, Intergenic, RNA, Long Noncoding
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