What fuels polypeptide translocation? An energetical view on mitochondrial protein sorting
Copyright policy )What fuels polypeptide translocation? An energetical view on mitochondrial protein sorting
Protein sorting into mitochondria is achieved by the concerted action of at least four translocation complexes. Vectorial transport of polypeptide chains by these complexes requires different driving forces. In particular, Deltapsi, matrix adenosine triphosphate and the free energy of the binding to other protein components are used in series to achieve sorting of proteins to the various mitochondrial subcompartments. The processes providing the translocation energy are presented in this review and their impact for protein sorting into and within mitochondria is discussed.
Protein Folding, Biophysics, Biochemistry, Membrane Potentials, Adenosine Triphosphate, Bacterial Proteins, Membrane potential, Adenosine Triphosphatases, Protein translocation, SecA Proteins, Escherichia coli Proteins, Molecular Motor Proteins, Membrane Transport Proteins, Cell Biology, Intracellular Membranes, Mitochondria, Protein Transport, Eukaryotic Cells, Translocase, Brownian ratchet, Driving force, Carrier Proteins, SEC Translocation Channels, Adenosine triphosphate, Protein Binding
Protein Folding, Biophysics, Biochemistry, Membrane Potentials, Adenosine Triphosphate, Bacterial Proteins, Membrane potential, Adenosine Triphosphatases, Protein translocation, SecA Proteins, Escherichia coli Proteins, Molecular Motor Proteins, Membrane Transport Proteins, Cell Biology, Intracellular Membranes, Mitochondria, Protein Transport, Eukaryotic Cells, Translocase, Brownian ratchet, Driving force, Carrier Proteins, SEC Translocation Channels, Adenosine triphosphate, Protein Binding
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