Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1
Copyright policy )Regulation of ribosomal RNA synthesis in T cells: requirement for GTP and Ebp1
Key PointsMPA suppresses ribosomal RNA (rRNA) synthesis and cell proliferation in T cells through TIF-IA, a GTP binding protein. The combination of MPA and sotrastaurin potently suppresses T-cell proliferation and inhibits IL-2 secretion through TIF-IA and ErbB3-binding protein 1 (Ebp1).
- University of Maryland, Baltimore United States
- University of Maryland School of Medicine United States
- Stanford University United States
- Stanford Cancer Institute United States
Blotting, Western, Gene Expression, Keratin-20, Mycophenolic Acid, Lymphocyte Activation, DNA, Ribosomal, Jurkat Cells, Protein Kinase C-delta, HEK293 Cells, Proliferating Cell Nuclear Antigen, Mutation, Humans, Guanosine Triphosphate, Phosphorylation, Promoter Regions, Genetic, Pol1 Transcription Initiation Complex Proteins, Cells, Cultured, Adaptor Proteins, Signal Transducing, Cell Proliferation, Protein Binding
Blotting, Western, Gene Expression, Keratin-20, Mycophenolic Acid, Lymphocyte Activation, DNA, Ribosomal, Jurkat Cells, Protein Kinase C-delta, HEK293 Cells, Proliferating Cell Nuclear Antigen, Mutation, Humans, Guanosine Triphosphate, Phosphorylation, Promoter Regions, Genetic, Pol1 Transcription Initiation Complex Proteins, Cells, Cultured, Adaptor Proteins, Signal Transducing, Cell Proliferation, Protein Binding
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