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Article . 2000 . Peer-reviewed
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Article . 2000
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The Genome Sequence of Drosophila melanogaster

Authors: Mark D. Adams; Susan E. Celniker; Robert A. Holt; Cheryl A. Evans; Jeannine D. Gocayne; Peter G. Amanatides; Steven E. Scherer; +189 Authors

The Genome Sequence of Drosophila melanogaster

Abstract

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the ∼120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes ∼13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.

Keywords

DNA Replication, Genome, DNA Repair, Transcription, Genetic, Computational Biology, Nuclear Proteins, Biological Transport, Genes, Insect, Sequence Analysis, DNA, Chromatin, Euchromatin, Contig Mapping, Drosophila melanogaster, Cytochrome P-450 Enzyme System, Heterochromatin, Protein Biosynthesis, Animals, Insect Proteins, Cloning, Molecular, Gene Library

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5K
Top 0.01%
Top 0.01%
Top 0.01%
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