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Hsp90b1 knockout targeted to male germline: a mouse model for globozoospermia

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2011 English Publisher:Elsevier BVJournal:Fertility and Sterility, volume 95, pages 1,475-14,770,000 (issn: 0015-0282,

Authors: Christophe Audouard; Elisabeth S. Christians;

doi: 10.1016/j.fertnstert.2010.12.006

pmid: 21208614

Hsp90b1 knockout targeted to male germline: a mouse model for globozoospermia

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Abstract

To study the role of Hsp90β1, an endoplasmic chaperone, we have built a conditional knockout by crossing Hsp90β1(flox/flox) with the Vasa-Cre transgenic line. Spermatozoa deficient in Hsp90β1 could not naturally fertilize oocytes and exhibited large and globular heads with abnormal intermediate pieces, a phenotype reminiscent of human globozoospermia.

Related Organizations

Paul Sabatier University
France
University of Toulouse
France

Keywords

Male, Mice, Knockout, Mice, Transgenic, Spermatozoa, Disease Models, Animal, Mice, Pregnancy, Gene Targeting, Animals, Female, HSP90 Heat-Shock Proteins, Infertility, Male

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26 Research products, page 1 of 3

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	55
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