Jil-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (Msl) Dosage Compensation Complex
Copyright policy )Jil-1, a Chromosomal Kinase Implicated in Regulation of Chromatin Structure, Associates with the Male Specific Lethal (Msl) Dosage Compensation Complex
JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL-1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.
- Iowa State University United States
Male, X Chromosome, Transcription, Genetic, Gene Dosage, 610, Gene Expression Regulation, Enzymologic, Molecular Genetics, Histones, Cell and Developmental Biology, Genetics, Animals, Drosophila Proteins, Phosphorylation, MSL complex, Nuclear Proteins, protein kinase, Chromatin, DNA-Binding Proteins, dosage compensation, chromatin, Insect Proteins, Drosophila, Female, Protein Kinases, Protein Binding, Transcription Factors
Male, X Chromosome, Transcription, Genetic, Gene Dosage, 610, Gene Expression Regulation, Enzymologic, Molecular Genetics, Histones, Cell and Developmental Biology, Genetics, Animals, Drosophila Proteins, Phosphorylation, MSL complex, Nuclear Proteins, protein kinase, Chromatin, DNA-Binding Proteins, dosage compensation, chromatin, Insect Proteins, Drosophila, Female, Protein Kinases, Protein Binding, Transcription Factors
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