Klebsiella pneumoniaeST307 withblaOXA-181,South Africa, 2014–2016
Copyright policy )Klebsiella pneumoniaeST307 withblaOXA-181,South Africa, 2014–2016
Klebsiella pneumoniae sequence type (ST) 307 is an emerging global antimicrobial drug-resistant clone. We used whole-genome sequencing and PCR to characterize K. pneumoniae ST307 with oxacillinase (OXA) 181 carbapenemase across several private hospitals in South Africa during 2014-2016. The South Africa ST307 belonged to a different clade (clade VI) with unique genomic characteristics when compared with global ST307 (clades I-V). Bayesian evolution analysis showed that clade VI emerged around March 2013 in Gauteng Province, South Africa, and then evolved during 2014 into 2 distinct lineages. K. pneumoniae ST307 clade VI with OXA-181 disseminated over a 15-month period within 42 hospitals in 23 cities across 6 northeastern provinces, affecting 350 patients. The rapid expansion of ST307 was most likely due to intrahospital, interhospital, intercity, and interprovince movements of patients. This study highlights the importance of molecular surveillance for tracking emerging antimicrobial clones.
- University of Calgary Canada
- Rutgers, The State University of New Jersey United States
- University of Pretoria South Africa
- Public Health Research Institute United States
- National Health Laboratory Service South Africa
Patients, carbapenemases, Infectious and parasitic diseases, RC109-216, Klebsiella pneumoniae sequence type 307, Communicable Diseases, Emerging, beta-Lactam Resistance, beta-Lactamases, Evolution, Molecular, Klebsiella pneumoniae ST307, South Africa, Enterobacteriaceae, Bacterial Proteins, Humans, antimicrobial resistance, Phylogeny, Molecular Epidemiology, outbreak, Research, R, Gauteng Province, Hospitals, Klebsiella Infections, genomic surveillance, Klebsiella pneumoniae, Medicine, Genome, Bacterial
Patients, carbapenemases, Infectious and parasitic diseases, RC109-216, Klebsiella pneumoniae sequence type 307, Communicable Diseases, Emerging, beta-Lactam Resistance, beta-Lactamases, Evolution, Molecular, Klebsiella pneumoniae ST307, South Africa, Enterobacteriaceae, Bacterial Proteins, Humans, antimicrobial resistance, Phylogeny, Molecular Epidemiology, outbreak, Research, R, Gauteng Province, Hospitals, Klebsiella Infections, genomic surveillance, Klebsiella pneumoniae, Medicine, Genome, Bacterial
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