Shalya Tantra is a significant branch of Ayurveda. The name of the sage-physician Susruta is well known in the field of surgery. Many surgical and para-surgical techniques have been described for the management of various diseases. Vrana is one of them which have been managed by a human being from starting of civilization. Under the circumstances, the first thing which the man came across was the injury from different sources which was causing Vrana (wound). The wound is very common in both developed and developing countries. It is a breach in the normal tissue continuum, resulting in a variety of cellular & molecular sequel. A wound is a major health problem because the incidence of severe complications is high & financial resources are limited. Vrana is an important chapter of Shalya Tantra due to its involvement in many surgical conditions. This, phenomena of Vrana is not only limited to the cutaneous lesion but may also extend up to muscles blood vessels, ligaments, bones, joints, visceral organs and other vital parts of the body. The diagnostic criterion has been dealt in a very detailed manner by Acharya Susruth. In this article, efforts have been made to throw light on the pathology of Vrana, its classification, diagnosis, and it’s healing.