Mapping of the gene encoding the α-subunit of the human H+, K+-ATPase to chromosome 19q13.1 by fluorescent in Situ hybridization
Copyright policy )Mapping of the gene encoding the α-subunit of the human H+, K+-ATPase to chromosome 19q13.1 by fluorescent in Situ hybridization
band (Fig. 1). To our knowledge, this is the first human chromosomal localization of an enzyme metabolizing InsP 3. A screening of the Genome DataBank and Online Mendel ian Inheri tance in Man from April 1992 failed to reveal any candidate disease tha t might be explained in single terms by mutat ion of the gene. The data clearly establish that despite their sequence similarity (ca. 65%) indicating a common evolutionary origin, hh39R and hh3 clones encoding two InsP 3 3-kinase isozymes are associated with different genes on different chromosomes.
- University of Michigan–Ann Arbor United States
- University of Michigan United States
- University of Michigan–Flint United States
- Eastern Michigan University United States
Science, Molecular, Chromosome Mapping, H(+)-K(+)-Exchanging ATPase, Biological Chemistry, Karyotyping, Health Sciences, Genetics, Humans, Cellular and Developmental Biology, Chromosomes, Human, Pair 19, In Situ Hybridization, Fluorescence
Science, Molecular, Chromosome Mapping, H(+)-K(+)-Exchanging ATPase, Biological Chemistry, Karyotyping, Health Sciences, Genetics, Humans, Cellular and Developmental Biology, Chromosomes, Human, Pair 19, In Situ Hybridization, Fluorescence
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