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Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1991 English Publisher:Springer Science and Business Media LLCJournal:Biochemical Genetics, volume 29, pages 545-557 (issn: 0006-2928, eissn: 1573-4927,

Authors: A. Gaa; Juliane Gröning; Otto von Deimling;

doi: 10.1007/pl00020697 , 10.1007/bf02426870

pmid: 1820020

Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1

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Abstract

Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characterized by the absence of a corresponding protease band. A third phenotype, CTRA-1C, was observed in IS/Cam and a fourth phenotype, CTRA-1D, was detected in SEG/1. CTRA-1 was found only in the pancreas and may represent the A form of chymotrypsin. The enzyme was shown to be controlled by the presumed structural locus Ctra-1 located on chromosome 8. From two backcross series, including a total of 274 animals, the gene order (Es-1, Es-9)-3.9 +/- 1.7%-Got-2-3.9 +/- 1.7%-(Es-2, Es-7, Es-23)-0.7 +/- 0.5%- Ctra-1-6.3 +/- 2.2%-Prt-2 was established.

Related Organizations

University of Freiburg
Germany

Keywords

Genetic Markers, Male, Chromosome Mapping, Mice, Inbred Strains, Substrate Specificity, Isoenzymes, Mice, Phenotype, Genes, Species Specificity, Animals, Chymotrypsin, Female, Isoelectric Focusing, Pancreas, Crosses, Genetic

7 Research products, page 1 of 1

Uncharacterized protein
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Uncharacterized protein
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Chymotrypsinogen B
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Aspartate aminotransferase, mitochondrial
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Carboxylesterase 1C
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MFLJ00366 protein
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